ArticleACS biomaterials science & engineering2026
Molecular Weight-Driven Tunable Hyaluronic Acid-Based Hydrogels Modulate Immune Polarization in Three-Dimensional Microenvironments.
Article in ACS biomaterials science & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dynamic Tuning of MSC-Based Scaffolds for Neurological Protection After Brain or CNS Injury.Life (Basel, Switzerland) · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
Macrophages exhibit phenotypic plasticity that is strongly influenced by their surrounding microenvironment, including extracellular matrix (ECM) components. Hyaluronic acid (HA), a major glycosaminoglycan in ECM, has immunomodulatory effects that are highly dependent on its molecular weight (MW). However, most previous studies have been limited to two-dimensional (2D) culture systems, which were unable to accurately replicate the in vivo environment. In this study, we utilized a three-dimensional (3D) culture system based on HA-based hydrogels to better understand the MW-dependent immunomodulatory effects of HA on macrophages under more physiologically relevant conditions. Three different MWs of HA were chemically modified and cross-linked with PEG-SH
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