Evidence map›Paper›PMID 41854515›Full record

ArticleJournal of neuropsychology2026

Neural correlates of pure apathy in multiple sclerosis: An exploratory neuroimaging study.

Valentina Torchia, Vera Gramigna, Mariachiara Gaita, Daniele Spitaleri, Antonio Costanzo, Liana Palermo, Florindo d'Onofrio, Simona Raimo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuropsychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Valentina TorchiaDepartment of Health Sciences, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.
Vera GramignaDepartment of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.
Mariachiara GaitaDepartment of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Daniele SpitaleriNeurology Unit, San Giuseppe Moscati Hospital, Avellino, Italy.
Antonio CostanzoDepartment of Humanities, University of Federico II, Naples, Italy.
Liana PalermoDepartment of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.
Florindo d'OnofrioNeurology Unit, San Giuseppe Moscati Hospital, Avellino, Italy.
Simona RaimoDepartment of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0002-0687-9656

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pure apathy is relatively common in people with Multiple Sclerosis (PwMS), but its neural mechanisms remain unexplored. Therefore, we investigated the neural correlates of pure apathy in PwMS, differentiating it from depression. Sixty-two PwMS underwent neuropsychological assessments and Magnetic Resonance Imaging scans. Pure apathy is primarily associated with lesions in the cortical-limbic-subcortical system implicated in goal-directed behaviour and motivation. Apathy and depression arise from distinct yet partially overlapping neural mechanisms, with basal ganglia and limbic structures playing a key role.

Indexed as

ApathyBrainMultiple SclerosisAdultBrain MappingDepressionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological Testsapathybasal gangliadepressionMRImultiple sclerosis

Identifiers

PMID41854515
PMCPMC13552241

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.