Evidence map›Paper›PMID 41854426›Full record

ArticleJournal of bacteriology2026

TraN variants mediate conjugation species specificity of IncA/C, IncH, and

Shan He, Sophia David, Jaie Rattle, Julia Sanchez-Garrido, Wen Wen Low, Joshua L C Wong, Konstantinos Beis, Gad Frankel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shan HeDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Sophia DavidCentre for Genomic Pathogen Surveillance, Pandemic Sciences Institute, University of Oxford, Oxford, United Kingdom.
Jaie RattleDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Julia Sanchez-GarridoDepartment of Life Sciences, Imperial College London, London, United Kingdom.ORCID 0000-0002-5847-4167
Wen Wen LowDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Joshua L C WongDepartment of Life Sciences, Imperial College London, London, United Kingdom.ORCID 0000-0001-8437-6731
Konstantinos BeisDepartment of Life Sciences, Imperial College London, London, United Kingdom.ORCID 0000-0001-5727-4721
Gad FrankelDepartment of Life Sciences, Imperial College London, London, United Kingdom.ORCID 0000-0002-0046-1363

Funding

Wellcome TrustWellcome Trust 224282/Z/21/Z
6 · The paper itself

Abstract

IncA/C and IncH plasmids commonly carry antimicrobial resistance genes, notably IMPORTANCE: Plasmid conjugation drives the spread of antimicrobial resistance genes between different bacterial species. In IncF plasmids, this process relies on tight interactions between an outer-membrane protein in the recipient and the plasmid-encoded TraN, which consists of conserved base and variable tip domains. So far, TraN was only studied in IncF plasmids. We show that IncA/C and IncH plasmids encode a larger TraN with distinct isoforms that shape host range and species specificity. We also identify a novel TraN variant in

Indexed as

Acinetobacter baumanniiConjugation, GeneticPlasmidsBacterial Outer Membrane ProteinsBacterial ProteinsSpecies SpecificityBacterial Outer Membrane ProteinsBacterial Proteinsantimicrobial resistancebioinformaticsCitrobacterEscherichia colihorizontal gene transferIncA/C and IncH plasmidsKlebsiella pneumoniaeplasmid conjugation

Identifiers

PMID41854426
PMCPMC13104618

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.