ArticleScience progress
Seroprevalence and spatial distribution of immunoglobulin (IgG) antibodies against human parvovirus B19 in voluntary blood donors from Shaanxi Province, China: A cross-sectional study.
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14 authors.
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Abstract
ObjectiveSince late 2023, human parvovirus B19 (B19V) has been erupting continuously in multiple countries. Although transfusion-transmitted infections remain rarely documented, donations harbouring high-titre, undetected virus could still breach current pathogen-reduction processes and pose a potential threat to the safety of blood and blood products. To evaluate local risk, this study first determines the immunoglobulin G (IgG) seroprevalence of B19V and its geographic distribution among voluntary blood donors in Shaanxi Province.MethodsIn this cross-sectional study, from August to December 2024, an enzyme-linked immunosorbent assay was used to detect the IgG antibody against B19V in sampled batches of qualified blood samples from five municipal central blood stations in Shaanxi Province, and the distribution characteristics of samples were analysed from multiple perspectives.ResultsIn Shaanxi Province, the B19V IgG antibody positivity rate was 24.95% (533 out of 2136), and increased with age (
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