ArticleJACC. Case reports2026
Patient-Specific 3D Coronary Reconstruction and Computational Simulations to Guide Drug-Coated Balloon Intervention: First-in-Human Experience.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A review of the pathogenic mechanism and clinical management progress of in-stent calcification restenosis.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn-stent restenosis (ISR) continues to be a significant challenge in percutaneous coronary intervention, making patient selection and lesion preparation critical for successful drug-coated balloon therapy. REPORT SUMMARY: We report the first-in-human use of the AGENT paclitaxel-coated balloon in the United States, guided by patient-specific 3-dimensional coronary reconstruction and computational simulations. This computational simulation-informed strategy identified stiff fibrotic ISR, guiding lesion preparation with excimer laser coronary atherectomy, and noncompliant and cutting balloon inflations before drug-coated balloon deployment. Recurrent ISR at 8 months was successfully treated using the same simulation-guided approach with optimized device sizing. DISCUSSION: Patient-specific computational simulations that integrated individual anatomy, physiology, and biology provided guidance on lesion preparation and device selection, leading to favorable clinical outcomes. NOVELTY: This report presents the first computational simulation-guided drug-coated balloon treatment of ISR integrating patient-specific anatomy, physiology, and biology. TAKE-HOME MESSAGES: Computational simulations combined with intracoronary imaging can enhance preprocedural planning, device selection, and outcomes in coronary interventions.
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Registered trials
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