ArticleArthritis & rheumatology (Hoboken, N.J.)2026
Functional Impact of Structural Damage in Psoriatic Arthritis: Insights from a Prospective Cohort Study.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the association between radiographic structural damage and physical function (PF) in psoriatic arthritis (PsA).
methodsData were analyzed from a large longitudinal PsA cohort. PF was measured using the Health Assessment Questionnaire (HAQ, 0-3) and Short Form-36 PF subscale (SF-36, 0-100); radiographic joint damage was measured using the modified Steinbrocker score (mSS, 0-168). Associations between PF and mSS were analyzed using linear mixed models. We also evaluated the impact of the presence of any damaged joint (grade 2-4), joint damage by individual grades, and the number of damaged joints (grade 2-4) per patient on PF.
resultsOf 1,177 patients (mean ± SD age 44.61 ± 12.76 years; 55.8% men), baseline mSS was 2 (interquartile range [IQR] 0-8.5), HAQ was 0.62 (IQR 0.12-1.12), and SF-36 PF was 60 (IQR 35-85). Higher mSS was significantly associated with worse SF-36 PF (β = -0.10; 95% confidence interval [CI] -0.15 to -0.05) and HAQ (β = 0.003; 95% CI 0.002 to 0.004) after controlling for swollen joint count, sex, and disease duration. The number of damaged joints was associated with worse SF-36 PF (β = -0.23; 95% CI -0.38 to -0.08) and HAQ (β = 0.005; 95% CI 0.002 to 0.009). The presence of a damaged joint (grade 2-4) alone did not impact PF. However, the presence of a joint with grade 4 destruction was associated with substantially worse SF-36 PF (β = -3.04; 95% CI -5.93 to -0.15) and HAQ (β = 0.09; 95% CI 0.03 to 0.15). Increasing counts of grade 4 joints demonstrated a strong dose response with SF-36 PF (β = -0.54; 95% CI -0.81 to -0.26) and HAQ (β = 0.01; 95% CI 0.01 to 0.02).
conclusionRadiographic structural damage, particularly severe joint destruction, is independently associated with impaired PF in PsA, highlighting the importance of early detection and prevention of damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.