Evidence map›Paper›PMID 41854215›Full record

ArticleCanadian respiratory journal2026

Validity of Alfred Step Test Exercise Protocol (A-STEP) as a Surrogate VO

Brenda Button, Mahesh Dharmakumara, Lisa Wilson, Nic Parry, Faizel Hartley, Brigitte Borg, Dominic T Keating

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brenda ButtonThe Alfred, Melbourne, Australia, alfred.org.au.ORCID 0000-0002-3044-8872
Mahesh DharmakumaraThe Alfred, Melbourne, Australia, alfred.org.au.
Lisa WilsonThe Alfred, Melbourne, Australia, alfred.org.au.
Nic ParryThe Alfred, Melbourne, Australia, alfred.org.au.
Faizel HartleyThe Alfred, Melbourne, Australia, alfred.org.au.
Brigitte BorgThe Alfred, Melbourne, Australia, alfred.org.au.
Dominic T KeatingThe Alfred, Melbourne, Australia, alfred.org.au.

Funding

Alfred FoundationCouncil of Australasian University LibrariansMonash University
6 · The paper itself

Abstract

backgroundThe Alfred Step Test Exercise Protocol (A-STEP) and feasibility study were previously published. The aim here was to determine the validity of the A-STEP compared to cycle ergometry (CPET) in adults with CF.

methodsThe A-STEP and CPET were carried out in random order 2 weeks apart. A wearable, portable metabolic system was used to measure breath-by-breath and minute-by-minute sampling of O

resultsSeven stable-state adults (3 male) on CFTR modulator therapy with a mean (SD) and range of age 38.2 (13.4) 26-64 years; height 169.9 (10.9) 149.7-185.3 cm; BMI 22.8 (2.10) 19.5-28 kg/m

conclusionThe A-STEP may be a portable, valid surrogate to cardiopulmonary exercise testing using cycle ergometry.

Indexed as

Cystic FibrosisExercise TestOxygen ConsumptionAdultErgometryFeasibility StudiesFemaleHeart RateHumansMaleMiddle AgedReproducibility of Results

Identifiers

PMID41854215
PMCPMC13140811

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.