Evidence map›Paper›PMID 41854206›Full record

ArticleJournal of cachexia, sarcopenia and muscle2026

Multi-Parametric MRI Approach at 3 T and 7 T for Assessing Skeletal Muscle Pathology in Myofibrillar Myopathies: A Pilot Study.

Claudius S Mathy, Lena V Gast, Christian Holtzhausen, Teresa Gerhalter, Christoph Stuprich, Matthias Türk, Rafael Heiss, Benjamin Marty, Frederik B Laun, Julia V Wanschitz and 6 more

Abstract read
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Claudius S MathyInstitute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.ORCID https://orcid.org/0000-0002-6834-3355
Lena V GastInstitute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Christian HoltzhausenInstitute of Neuropathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Teresa GerhalterInstitute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Christoph StuprichInstitute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Matthias TürkDepartment of Neurology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Rafael HeissInstitute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Benjamin MartyNMR Laboratory, Institute of Myology, Paris, France.
Frederik B LaunInstitute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Julia V WanschitzDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Simon HametnerDivision of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Germany.
Arnd DörflerDepartment of Neuroradiology, Universitätsklinikum, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Michael UderInstitute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Tobias BäuerleInstitute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Armin M NagelInstitute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.ORCID https://orcid.org/0000-0003-0948-1421
Rolf SchröderInstitute of Neuropathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Funding

German Research Foundation (DFG) 500888779/RU5534
6 · The paper itself

Abstract

backgroundMyofibrillar myopathies (MFM) form a large group of clinically and genetically heterogeneous protein aggregate diseases. We investigated whether a novel quantitative MRI protocol can reveal new aspects of structural and biochemical muscle pathology in three classic MFM subtypes.

methodsMRI of the lower legs was performed in nine MFM patients with filamin-C (FLNC; n = 5), desmin (DES, n = 2) and LIM domain binding 3 (LDB3; n = 2) gene mutations, one patient with non-MFM, filamin-C related distal myopathy (4 males, 6 females, 51.0 ± 7.7 years) and 10 age-matched healthy control subjects (5 males, 5 females, 50.0 ± 11.0 years).

resultsT

conclusionsQuantitative PDFF measurements and water T

Indexed as

Magnetic Resonance ImagingMuscle, SkeletalMyopathies, Structural, CongenitalAdaptor Proteins, Signal TransducingAdultCase-Control StudiesDesminFemaleFilaminsHumansLIM Domain ProteinsMaleMiddle AgedPilot ProjectsAdaptor Proteins, Signal TransducingDesminFilaminsLDB3 protein, humanLIM Domain Proteinsdistal myopathymyofibrillar myopathyquantitative MRIsodium (23Na) and potassium (39K) MRIultra‐high field MRI

Identifiers

PMID41854206
PMCPMC13140330

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.