Evidence map›Paper›PMID 41854199›Full record

ArticleJournal of natural products2026

Structure Elucidation, Biosynthesis and Biological Evaluation of Neosorangicin A, a Member of the Sorangicin Family.

Franziska Fries, Sebastian Walesch, Rolf Jansen, Kristin von Peinen, Luisa Mehr, Linda Pätzold, Sabrina Karwehl, Andreas M Kany, Ronald Garcia, Silke Reinecke and 6 more

Abstract read
In one paragraph

Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Franziska FriesHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbrücken 66123, Germany.ORCID 0009-0009-6485-8317
Sebastian WaleschHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbrücken 66123, Germany.
Rolf JansenGerman Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Braunschweig 38124, Germany.
Kristin von PeinenHelmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, Braunschweig 38124, Germany.
Luisa MehrHelmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, Braunschweig 38124, Germany.ORCID 0009-0002-0307-4526
Linda PätzoldInstitute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar 66421 , Germany.
Sabrina KarwehlHelmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, Braunschweig 38124, Germany.
Andreas M KanyHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbrücken 66123, Germany.
Ronald GarciaHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbrücken 66123, Germany.
Silke ReineckeGerman Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Braunschweig 38124, Germany.
Jörg HaupenthalHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbrücken 66123, Germany.
Theresia E B StradalHelmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, Braunschweig 38124, Germany.
Markus BischoffHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbrücken 66123, Germany.ORCID 0000-0001-6734-2732
Marc StadlerGerman Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Braunschweig 38124, Germany.ORCID 0000-0002-7284-8671
Rolf MüllerHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbrücken 66123, Germany.
Jennifer HerrmannHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy, Saarland University, Campus E8 1, Saarbrücken 66123, Germany.ORCID 0000-0003-3398-9938

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance represents an escalating global health crisis, with drug-resistant infections predicted to cause up to 10 million deaths annually by 2050, underscoring the urgent need for novel antibiotics. Natural products play a crucial role in the discovery and development of antibiotics, with myxobacteria emerging as a particularly promising source due to their ability to produce structurally diverse and bioactive compounds. One prominent example of antibiotics from myxobacteria are the sorangicins, potent inhibitors of the bacterial RNA polymerase (RNAP). Here, we report the isolation of two unprecedented compounds, neosorangicin A (

Indexed as

Anti-Bacterial AgentsMyxococcalesAnimalsDNA-Directed RNA PolymerasesGram-Positive BacteriaMiceMicrobial Sensitivity TestsMolecular StructureMycobacterium tuberculosisStaphylococcus aureusAnti-Bacterial AgentsDNA-Directed RNA Polymerases

Identifiers

PMID41854199
PMCPMC13122636

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.