Evidence map›Paper›PMID 41854164›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors.

Zhi Xu, Prasun Mukherjee, Steven Gossert, Stephen Thomas, Vasil H Vasilev, Eric R Welin, Yichen Tan, Shane M McKenna, Megan A Emmanuel, Todd K Hyster

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhi XuDepartment of Chemistry, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0002-1476-1367
Prasun MukherjeeDepartment of Chemistry, Princeton University, Princeton, New Jersey, USA.
Steven GossertIntegrated Materials Engineering & Technology, Bristol Myers Squibb, New Brunswick, New Jersey, USA.
Stephen ThomasIntegrated Materials Engineering & Technology, Bristol Myers Squibb, New Brunswick, New Jersey, USA.
Vasil H VasilevDiscovery & Development Sciences, Bristol Myers Squibb, San Diego, California, USA.
Eric R WelinDiscovery & Development Sciences, Bristol Myers Squibb, San Diego, California, USA.
Yichen TanChemical Process Development, Bristol Myers Squibb, New Brunswick, New Jersey, USA.
Shane M McKennaChemical Process Development, Bristol Myers Squibb Company, Wirral, UK.
Megan A EmmanuelChemical Process Development, Bristol Myers Squibb, New Brunswick, New Jersey, USA.
Todd K HysterDepartment of Chemistry, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0003-3560-355X

Funding

Hyster (Rivas-Souchet) Diversity SupplementR01GM127703 · NIGMS · PRINCETON UNIVERSITY · PI Todd Kurt Hyster · 2018 to 2026
$2.9M
NIGMS NIH HHS R01 GM127703NIH HHS NIGMS R01GM127703
6 · The paper itself

Abstract

We describe a photoenzymatic hydroalkylation reaction that enables the efficient and stereocontrolled synthesis of aryl glutarimide precursors-chemically and configurationally robust entry points to bioactive agents for targeted protein degradation. Screening of flavin-dependent "ene"-reductases identified GluER HA

Indexed as

PiperidonesAlkylationBiocatalysisPhotochemical ProcessesStereoisomerismglutarimidePiperidonesbiocatalysisdirected evolutionglutarimidephotoenzymatic catalysistargeted protein degradation

Identifiers

PMID41854164
PMCPMC13021314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.