Evidence map›Paper›PMID 41854105›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

Clinical Factors and Income Status are Associated with Depression and Anxiety in Head and Neck Cancer Patients.

Ashok R Jethwa, Catriona M Douglas, Katrina Hueniken, Geoffrey Liu, Andrew Bayley, Shao Hui Huang, Aaron Hansen, Douglas Chepeha, Leba M Sarkis, David P Goldstein and 3 more

Abstract read
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In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ashok R JethwaDepartment of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, MN, USA.
Catriona M DouglasDepartment of Otolaryngology-Head and Neck Surgery, Queen Elizabeth University Hospital, Glasgow, Scotland, UK.
Katrina HuenikenDepartment of Biostatistics, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
Geoffrey LiuDepartment of Biostatistics, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
Andrew BayleyDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Odette Cancer Centre, Toronto, ON, Canada.
Shao Hui HuangDepartment of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
Aaron HansenDepartment of Medical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
Douglas ChepehaDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-9062-3719
Leba M SarkisDepartment of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-3791-4925
David P GoldsteinDepartment of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
Madeline LiDepartment of Psychosocial Oncology and Palliative Care, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-3977-7437
Shayanne A LajudDepartment of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
John R de AlmeidaDepartment of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceDepression and anxiety affect a significant portion of head and neck cancer (HNC) patients. Furthermore, depression has been shown to result in decreased survival and worse functional outcomes.

objectiveThe purpose of this study is to determine the prevalence of depression and anxiety in a cohort of HNC patients at all subsites.

designThis is a retrospective review of prospectively gathered data in a cohort of patients aged 18 years of age and over, diagnosed with HNC, between August 2011 and December 2017, treated at the Princess Margaret Cancer Centre in Toronto, Canada. SETTING/

participantsAdult Patients with a new diagnosis of HNC treated at the Princess Margaret Cancer Center/University Health Network between August 2011 and December 2017 were included in the study. EXPOSURES: Patients were initially screened using the Direct Assessment and Response Tool (DART), which includes the Edmonton Symptom Assessment Scale (ESAS) to identify psychosocial distress.

main outcome measuresIf positive on DART, patients were then asked to complete the Generalized Anxiety Disorder 7-Item Scale and the Patient Health Questionnaire-9. Associations with anxiety/depression and variables were assessed using univariate and multivariate logistic regressionResults:A total of 586 patients were included in our study. The median age of the group was 60 (22-89 years), with a male predominance (78.2%). Most patients (78.8%) had advanced disease at diagnosis. The oropharynx was the most common site (46.5%). The prevalence of depression and anxiety was 13.1% and 9.9%, respectively. Multivariate analysis showed that nonmarried status, non-white ethnicity, disease progression, lower income, and increased out-of-pocket costs were associated with depression. Definitive surgery, ECOG ≥1, and lower income were associated with anxiety. Disease stage, smoking/drinking history, and HPV status were not associated with anxiety/depression.

conclusionsA portion of patients are at higher risk of developing sustained depression and anxiety at 12 months following treatment, which may be predicted early, facilitating early mental health intervention. RELEVANCE: Identifying factors associated with depression and anxiety in HNC patients will aid in providing early intervention.

Indexed as

AnxietyDepressionHead and Neck NeoplasmsIncomeAdultAgedFemaleHumansMaleMiddle AgedPrevalenceRetrospective Studiesanxietydepressionhead and neck cancermental healthpsychosocial distress

Identifiers

PMID41854105
PMCPMC13010033

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.