ArticleLab on a chip2026
Intensified lentiviral vector perfusion bioprocessing with a spiral inertial microfluidic cell retention device.
Article in Lab on a chip, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Fouling-Free Inertial Microfluidic Cell Clarification for Lentivirus Manufacturing.Biotechnology and bioengineering · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Scalable production of cell therapy doses relies on inexpensive, efficient production of gene delivery vectors, such as lentiviral vectors, in HEK293 cell culture. Intensified perfusion processes improve the volumetric productivity of cell culture by continuously supplying nutrients, oxygen, and media to cells while removing harmful metabolites, thereby enabling higher producer cell densities. Membrane filter-based cell retention devices commonly used in perfusion bioprocessing can experience significant clogging and fouling over long-term processes, which leads to the undesired retention of lentiviral vectors in the filter matrix. In this work, we used spiral microfluidic technology as a cell retention device to continuously harvest lentiviral vectors and remove metabolic waste from HEK293 cells in a bioreactor running high cell density perfusion cultures. With the spiral microfluidic device, we performed four perfusion culture runs with maximum cell densities between 15 × 10
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