Evidence map›Paper›PMID 41854019›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Bile acids are associated with baseline and longitudinal amyloid and tau pathology in patients with Alzheimer's disease.

Wenjie Fu, Xiaowen Chao, Ying Wang, Shu Liu, Jie Wang, Qi Huang, Ying Luan, Peiyang Luo, Yihui Guan, Yingren Mai and 6 more

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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wenjie FuDepartment of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Xiaowen ChaoCenter for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying WangDepartment of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
Shu LiuState Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China.
Jie WangDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Qi HuangDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Ying LuanDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Peiyang LuoCenter for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yihui GuanDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Yingren MaiDepartment of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Wei JiaCenter for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Alzheimer's Disease Neuroimaging Initiative
Qihao GuoDepartment of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
Tianlu ChenCenter for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaowei MaDepartment of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Fang XieDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0003-2667-281X

Funding

Brain science and brain-like research of Shanghai Sixth People's Hospital ynnkxyb202416Lingang Laboratory LGL-3142-ADB510100STI2030-Major Projects 2022ZD0213800the crossing research project of Second Xiangya Hospital 02220173the National Science Foundation of China 82071962the National Science Foundation of China 82201583the National Science Foundation of China 82270917the National Science Foundation of China 82470853the National Science Foundation of China 82471441the startup fund of Huashan Hospital, Fudan University 2017QD081
6 · The paper itself

Abstract

introductionAlzheimer's disease (AD), a neurodegenerative disease, involves early alterations in the gut microbiota. Bile acids (BAs), which are metabolites produced by the microbiota, may impact brain function through the gut-brain axis.

methodsBy reference to multimodal datasets from the Chinese Preclinical Alzheimer's Disease Study (n = 1397) and the Alzheimer's Disease Neuroimaging Initiative (n = 1275), we analyzed differences in BA levels and their associations with AD biomarkers.

resultsLithocholic acid (LCA) -family BAs are associated with the amyloid-β status. Longitudinal changes in BA levels correlated with amyloid and tau pathologies. LCA and the deoxycholic acid (DCA) family exhibited predictive value with respect to AD pathology. Imaging transcriptomic analyses suggested that BAs modulated amyloid pathology through multiple mechanisms. DISCUSSION: DCA- and LCA-family BAs were proposed as molecular bridges that connect age signatures with AD pathology. They represent a new avenue for the development of biomarkers and therapeutic interventions.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBile Acids and Saltstau ProteinsAgedAged, 80 and overBiomarkersBrainFemaleHumansLongitudinal StudiesMaleAmyloid beta-PeptidesBile Acids and SaltsBiomarkerstau ProteinsAlzheimer's diseaseamyloid depositionbile acidsdeoxycholic acidlithocholic acidtau pathology

Identifiers

PMID41854019
PMCPMC13093639

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.