ArticleExperimental physiology2026
The effects of bed rest on cardiometabolic health: A systematic review and meta-analysis.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The effects of bed rest on cardiometabolic health: A systematic review and meta-analysis.Experimental physiology · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Horizontal bed rest (HBR) and head-down tilt (HDT) are models of physical inactivity. In this systematic review and meta-analysis, we aimed to quantify changes in cardiometabolic outcomes during HBR and HDT in healthy adults. Following the PRISMA guidelines, we searched PubMed, Scopus, Web of Science and Cochrane Library until 1 October 2025. Included studies recruited healthy adults (≥18 years of age) undergoing ≥2 days of HBR or HDT. A meta-analysis with mean differences (MD) and 95% confidence intervals (CI), using random-effects modelling was conducted. Forty-four studies were included. HBR (≤14 days) reduced fasting glucose (MD, -0.15 mmol/L, P = 0.00033). HBR (≤14 days) and HDT (≤60 days) increased insulin (HBR: MD, 7.07 pmol/L; HDT: MD, 9.65 pmol/L; P < 0.0001). The homeostatic model assessment for insulin resistance was increased under both models (HBR ≤30 days: MD, 0.10, P = 0.0004; HDT ≤60 days: MD, 0.24, P < 0.0001). HDT lowered total cholesterol (MD: -13.89 mg/dL, P = 0.000467); HBR raised triglycerides (MD, 18.96 mg/dL, P < 0.0001), and high-density lipoprotein cholesterol was decreased in both models (HBR ≤14 days: MD, -4.53 mg/dL, P = 0.000608; HDT ≤60 days: MD, -6.89; P < 0.0001). C-Reactive protein was elevated in HBR (MD, 1.57; P < 0.0001), and tumour necrosis factor alpha was elevated in both (HBR ≤14 days: MD, 1.33, P < 0.0001; HDT ≤21 days: MD, 0.40; P = 0.00643). In conclusion, HBR and HDT induce model- and duration-specific changes in glucose metabolism and lipid profiles. Interventions that could mitigate these effects may be warranted.
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