ArticleAdvances in laboratory medicine2026
Calculation of reference intervals using an indirect approach from laboratory database.
Article in Advances in laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Intact Parathyroid Hormone Reference Intervals: Importance of Pre-Processing for Indirect Reference Interval Estimation.Diagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The establishment of reference intervals (RIs) for biochemical parameters is crucial for the accurate interpretation of laboratory test results and clinical decision-making. This study aims to evaluate the feasibility of determining RIs using an indirect approach, which analyzes routine clinical samples instead of recruiting healthy individuals, thus leveraging large datasets while applying strict statistical criteria to exclude pathological values. Methods: This is a prospective study in which patients fulfilling inclusion criteria were recruited from the routine primary care to achieve a high proportion of healthy individuals. Biochemical magnitudes as creatinine, esterified bilirubin, ferritin, and transferrin were analyzed. A patient exclusion protocol was implemented to minimize results suggestive of pathology but ensuring a sufficient sample size for the calculation of new RIs. The new ones were compared with the RIs used in the laboratory, provided by the manufacturer. Results: The comparison between the newly calculated RIs and the existing laboratory RIs did not reveal statistically significant differences. The indirect approach provided robust RIs while maintaining data quality and a sufficient sample size. Conclusions: The findings support the effectiveness of this indirect approach for RI determination, provided that rigorous data quality standards and adequate sample sizes are maintained. The adoption of these RIs in clinical practice could enhance diagnostic accuracy and optimize healthcare resource utilization.
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