ReviewAdvances in laboratory medicine2026
Association between HLA alleles and adverse drug reactions. Mechanisms involved.
Review in Advances in laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Adverse drug reactions (ADRs) represent a major public health problem. A significant subset of these reactions, particularly delayed-type hypersensitivity reactions and severe cutaneous adverse reactions (SCARs), show a strong association with specific alleles of the human major histocompatibility complex (HLA). The following review aims to summarize the current evidence on the associations between HLA alleles and ADR, covering both well-established associations and those with emerging evidence. The proposed immunological mechanisms for these adverse reactions are also outlined, including hapten/pro-hapten, pharmacological interaction with immune receptors (p-i) and the altered peptide models. Content: A systematic literature search was conducted in the PubMed database (MEDLINE) through April 2025, independently by the authors. A consensus was then reached, with a total of 56 articles being used in this review. Summary: A division by groups of drugs is established (antiretrovirals, aromatic antiepileptics, allopurinol, antibiotics and other drugs), indicating for each of them the HLA involved, the proposed mechanism, ethnicity in which the association was described and the degree of association. A table is included to facilitate consultation of key information. Outlook: HLA alleles play a critical role in the pathogenesis of numerous ADRs, and further studies are needed to clarify HLA-ADRs associations and the mechanisms involved.
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