Evidence map›Paper›PMID 41853627›Full record

ReviewIBRO neuroscience reports2026

The cerebro-cerebellar system: Integrative roles in motor control, cognition, and neuropsychiatric disorders.

Mst Mohona Khatun, Mohammad Shahangir Biswas, Munna Kumar Podder, Rubait Hasan, Mst Ayesha Siddika

Abstract readReview
In one paragraph

Review in IBRO neuroscience reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Early autism risk factors: a cohort study of children born very preterm at 5-years.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mst Mohona KhatunDepartment of Biochemistry and Biotechnology, Khwaja Yunus Ali University, Enayetpur, Chowhali, Sirajganj, Bangladesh.
Mohammad Shahangir BiswasDepartment of Biochemistry and Biotechnology, University of Science & Technology Chittagong (USTC), Foy's Lake, Zakir Hossain Road, Chittagong 4202, Bangladesh.
Munna Kumar PodderDepartment of Biochemistry and Biotechnology, Khwaja Yunus Ali University, Enayetpur, Chowhali, Sirajganj, Bangladesh.
Rubait HasanDepartment of Biochemistry and Biotechnology, Khwaja Yunus Ali University, Enayetpur, Chowhali, Sirajganj, Bangladesh.
Mst Ayesha SiddikaDepartment of Biochemistry and Biotechnology, University of Science & Technology Chittagong (USTC), Foy's Lake, Zakir Hossain Road, Chittagong 4202, Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cerebro-cerebellar system, a network of bidirectional loops between the cerebellum and cerebral cortex, is crucial for coordinating motor control, cognition, and emotion. Moving beyond its traditional role in motor coordination, contemporary research underscores the cerebellum's significant involvement in higher-order functions, including executive control, language, and social cognition. This review synthesizes current anatomical, functional, and clinical evidence to delineate the cerebellum's role in neuropsychiatric and neurodegenerative disorders such as schizophrenia, autism spectrum disorder (ASD), and ataxia. Unlike previous broad reviews, this article provides a structured framework that links cerebellar functional topography with disease-specific pathophysiological mechanisms. We particularly highlight the cellular substrates of cerebellar plasticity, such as Purkinje cell long-term depression (LTD). Our synthesis reveals that prior literature often lacks mechanistic depth and fails to integrate findings across structural, functional, and clinical domains. We conclude by proposing future research directions involving advanced neuroimaging, artificial intelligence, and targeted neuromodulation, thereby clarifying the cerebellum's integrative roles and underscoring its translational potential for novel therapeutic strategies.

Indexed as

AtaxiaAutism Spectrum DisorderCerebellumCerebral CortexCerebro-cerebellar LoopsLong-Term DepressionNeuroimagingNeuromodulationNeuroplasticitySchizophrenia

Identifiers

PMID41853627
PMCPMC12993411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.