ArticleClinical, cosmetic and investigational dermatology2026
Danggui Buxue Decoction Attenuates H
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Molecular mechanisms of traditional Chinese medicine in skin aging: a narrative review.Frontiers in pharmacology · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Skin aging is linked to oxidative stress, and functional decline of keratinocytes is a core feature. Common chemical anti-aging agents, such as retinoic acid, often cause skin irritation, whereas traditional Chinese medicine formulas, with multiple components and relatively low toxicity, may offer alternative strategies. Methods: To investigate its antiaging effects and mechanisms, an in vitro oxidative stress model was established using H2O2-treated human HaCaT cells. The cellular safety of Danggui Buxue Decoction was assessed by CCK-8 assay and cell morphology. The effects of pretreatment on cell viability, intracellular reactive oxygen species, superoxide dismutase and glutathione peroxidase activities, and malondialdehyde content were evaluated. Real-time quantitative PCR was used to determine the mRNA expression of senescence- and oxidative stress-related genes. Results: Exposure to 600 μmol/L H2O2 for 1 h established an oxidative stress model, reducing cell viability to 66.3%, increasing ROS and MDA levels, and decreasing SOD and GSH-Px activities. Danggui Buxue Decoction showed no cytotoxicity at 6.25-1600 μg/mL. Pretreatment with 400 μg/mL Danggui Buxue Decoction provided protection against oxidative damage, improving cell viability, lowering ROS and MDA levels, and restoring SOD and GSH-Px activities. Specifically, 400 μg/mL Danggui Buxue Decoction increased cell viability by 31.7%, enhanced SOD and GSH-Px activities by 91.3% and 32.2%, respectively, and reduced MDA content by 27.9%. Gene expression analysis indicated that pretreatment prevented the H Conclusion: Danggui Buxue Decoction exerts preventive antiaging protective effects on HaCaT cells by scavenging excess reactive oxygen species, preventing impairment of the endogenous antioxidant enzyme system, inhibiting lipid peroxidation, and regulating key genes such as SOD2, MMP1, PPARα, and P21, thereby interrupting the vicious cycle of oxidative stress-induced cellular senescence and supporting its potential as a natural anti-aging agent. In vivo and clinical studies are needed to validate the translational applicability of these findings in the future.
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Registered trials
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