Evidence map›Paper›PMID 41853542›Full record

ArticleFrontiers in microbiomes2024

Characterization of double humanized BLT-mice with stable engraftment of a human gut bacterial microbiome.

Lance Daharsh, Saroj Chandra Lohani, Amanda E Ramer-Tait, Qingsheng Li

Abstract read
In one paragraph

Article in Frontiers in microbiomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lance Daharsh *School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, United States.
Saroj Chandra Lohani *School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, United States.
Amanda E Ramer-TaitDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, United States.
Qingsheng LiSchool of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humanized mice with human-like immune systems are commonly used to study immune responses to human-specific pathogens. However, one limitation of using humanized mice is their native murine gut microbiota, which significantly differs from that in humans. Given the importance of the gut microbiome to human health, these differences may profoundly impact the ability to translate results from humanized mouse studies to humans. Further, there is a critical need for improved pre-clinical models to study the complex

Indexed as

BLT micedouble humanized micehuman gut microbiotamouse modelstable engraftment

Identifiers

PMID41853542
PMCPMC12993508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.