Evidence map›Paper›PMID 41853485›Full record

ArticleAdvances in radiation oncology2026

Relative Biological Effectiveness of Carbon Ion Versus Photon Radiation Therapy for Acute Radiation-Induced Esophagitis in Locally Advanced Non-small Cell Lung Cancer Derived From Normal Tissue Complication Probability Modeling.

Yonglong Liu, Ningyi Ma, Yaqi Li, Jing Mi, Xingwen Fan, Jian Chen, Junchao Chen, Ying Guo, Xiaoli Liu, Youling Su and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yonglong LiuDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China.
Ningyi MaDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China.
Yaqi LiShanghai Key Laboratory of Radiation Oncology, Shanghai, China.
Jing MiDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Xingwen FanShanghai Key Laboratory of Radiation Oncology, Shanghai, China.
Jian ChenDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China.
Junchao ChenDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Ying GuoDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Xiaoli LiuDepartment of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai, China.
Youling SuDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China.
Jingfang MaoDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China.
Guoliang JiangDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China.
Kailiang WuDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to evaluate the relative biological effectiveness (RBE) of carbon-ion radiation therapy (CIRT) versus photon radiation therapy for acute radiation-induced esophagitis (ARIE) in patients with locally advanced non-small cell lung cancer, based on TD₅₀ derived from normal tissue complication probability (NTCP) models. Methods and Materials: A total of 165 propensity score-matched pairs of patients with locally advanced non-small cell lung cancer treated with CIRT or photon radiation therapy between January 2016 and December 2023 were analyzed. ARIE (grade ≥2, National Cancer Institute Common Terminology Criteria for Adverse Events v5.0) during or within 3 months postradiation therapy was the primary endpoint. The Lyman-Kutcher-Burman (LKB) NTCP model was developed using maximum-likelihood estimation. Model performance was assessed via 3-fold cross-validation and area under the receiver operating characteristic curve. The estimated RBE value was the TD₅₀ ratio between the photon radiation therapy and CIRT groups. Results: Grade ≥2 ARIE was observed in 6.7% of patients treated with CIRT and 19.4% of those treated with photons ( Conclusions: LKB-based NTCP modeling offers a clinically oriented framework to estimate RBE value for CIRT. Larger patient cohorts and external validation are required to enhance the model's generalizability and clinical applicability.

Identifiers

PMID41853485
PMCPMC12993293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.