ArticleFrontiers in microbiomes2023
Gut microbiome variation in pulmonary TB patients with diabetes or HIV comorbidities.
Article in Frontiers in microbiomes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Beyond bacilli: integrating the microbiome into the TB research agenda.Gut microbes · 2026Review
- Gut microbiota profile in newly diagnosed pulmonary tuberculosis patients: an exploratory pilot study in southern India.Gut pathogens · 2025Article
- On exploring cross-sectional stability and persistence of microbiome in a multiple body site colorectal cancer dataset.Frontiers in microbiology · 2025Article
- Exploring gut microbiota and its predicted functions in pulmonary tuberculosis: A multi-regional study using public 16S datasets.PloS one · 2025Article
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Authors and funding
12 authors.
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Abstract
Background: The gut microbiota is known to play a critical role in shaping the host immunity, and metabolism and influences the onset and progression of both communicable and non-communicable diseases. This study assessed the gut microbiome of tuberculosis (TB) cases with diabetes mellitus (DM) or HIV comorbidities before anti-TB therapy and after the intensive phase anti-TB therapy. Methods: Ninety cases comprising 60 TB-only, 23 TB-DM, 7 TB-HIV were recruited, among which 35 TB-only, 10 TB-DM, 5 TB-HIV were also sampled after 2 months of anti-TB treatment. Total gut microbiome was detected by 16S rRNA gene sequencing of DNA extracted from collected stool specimen. The taxonomic and functional diversity of the different groups were compared in addition to changes that could occur after 2 months antibiotics use. Results: Compared to the healthy controls, the gut microbiome of all the TB cohorts was characterized by a significant decreased alpha diversity and significant compositional changes. All the three TB cohorts were enriched with inflammatory related microorganisms of the genera Conclusion: Our findings show a dysbiotic gut microbiome and associated upregulation of inflammation related microorganism in gut microbiome of TB individuals with or without comorbidity.
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