ArticleFrontiers in oncology2026
Development and clinical application of a postoperative complication prognosis prediction model for gastric cancer patients based on automated machine learning with body fat rate.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To develop an automated machine learning (AutoML) framework integrating body composition indices-notably Body Fat Rate (BFR)-and clinicopathological features for predicting postoperative complications in gastric cancer patients, addressing limitations of traditional body mass index (BMI) assessment and enhancing clinical translatability. Methods: In this retrospective cohort study, 1,023 gastric cancer patients undergoing radical gastrectomy (January 2020-January 2025) were enrolled across two hospitals (716 training, 307 testing). A dual-optimization workflow included: (1) Simultaneous feature selection and hyperparameter tuning via the Improved Hike Optimization Algorithm (IHOA); (2) Class imbalance mitigation using synthetic minority oversampling technique (SMOTE). Model performance was evaluated through accuracy, sensitivity, specificity, F1-score, area under the receiver operating characteristic curve (AUC-ROC), area under the precision-recall curve (AUC-PR), calibration curves, and decision curve analysis (DCA). Feature robustness was validated using least absolute shrinkage and selection operator regression, while SHapley Additive exPlanations (SHAP) interpreted predictor contributions. A MATLAB-based proof-of-concept prototype visualization tool was developed for implementation. Results: In independent testing, AutoML maintained robust performance (ROC-AUC = 0.9380, PR-AUC = 0.9262). DCA revealed greater net clinical benefit across risk thresholds (1%-93%) compared to conventional methods, with sustained high-level stability confirming superior generalizability. Calibration curves demonstrated optimal probabilistic prediction (lowest test-set Brier score = 0.111). SHAP analysis identified BFR, visceral fat density (VFD), visceral fat area (VFA), skeletal muscle area (SMA), C-reactive protein (CRP), BMI, Age and lymphadenectomy extent as key predictors. Conclusion: The AutoML prediction model developed in this study achieves both high precision and strong interpretability. Its visualized tool effectively overcomes barriers to clinical translation, providing intelligent decision support for early warning and personalized intervention of postoperative complications in gastric cancer.
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