Evidence map›Paper›PMID 41853301›Full record

ArticleGenomic psychiatry : advancing science from genes to society2025

Prepartum bumetanide treatment reverses altered neonatal social communication but nonspecifically reduces postpubertal social behavior in a mouse model of fragile X syndrome.

Yui Sakamoto, Takeshi Takano, Shuji Shimoyama, Takeshi Hiramoto, Noboru Hiroi, Kazuhiko Nakamura

Abstract read
In one paragraph

Article in Genomic psychiatry : advancing science from genes to society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Research square · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yui SakamotoDepartment of Neuropsychiatry, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan 036-8562.ORCID 0000-0001-6845-1287
Takeshi TakanoDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA 78229.ORCID 0000-0002-0669-0175
Shuji ShimoyamaDepartment of Neurophysiology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan 036-8562.ORCID 0000-0001-6777-0438
Takeshi HiramotoDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA 78229.ORCID 0000-0002-8205-5579
Noboru HiroiDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA 78229.ORCID 0000-0002-6846-5969
Kazuhiko NakamuraDepartment of Neuropsychiatry, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan 036-8562.ORCID 0000-0001-7375-5867

Funding

Postnatal mechanisms of cognitive development in miceR01MH099660 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Noboru Hiroi · 2013 to 2026
$5.9M
Structure and Function of Neonatal Social Communication in Genetic Mouse Models of AutismR01DC015776 · NIDCD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HIROI, NOBORU · 2017 to 2021
$1.7M
Predicting the developmental trajectories of cognitive and motor dimensions from preterm neonatal vocalizationsR21HD105287 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HIROI, NOBORU · 2021 to 2022
$442k
Molecular and Cellular Mechanisms of Chromosome 18q23 DysmyelinationR03HD108551 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CODY, JANNINE DE MARS, HIROI, NOBORU · 2023 to 2024
$233k
NICHD NIH HHS R03 HD108551NICHD NIH HHS R21 HD105287NIDCD NIH HHS R01 DC015776NIMH NIH HHS R01 MH099660
6 · The paper itself

Abstract

Fragile X syndrome is caused by monogenic silencing of the

Indexed as

critical periodFmr1FMRPFragile XGABAmachine learningpredictorssocial communicationsocial interaction

Identifiers

PMID41853301
PMCPMC12994368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.