ArticleFrontiers in immunology2026
Sex-associated transcriptional changes to synovial macrophages in the aging joint.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Editorial: Characterising the functional heterogeneity of synovial macrophages.Frontiers in immunology · 2026Article
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11 authors.
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Abstract
Background: Synovial macrophages are critical to tissue maintenance and immune homeostasis in the joints. However, the function of synovial macrophages is compromised with age, leading to increased susceptibility to chronic inflammation and arthritis. Here, we compare the transcriptional heterogeneity of synovial macrophages in young and old joints from male and female mice to better understand the impact of aging and the role of sex. Methods: We compared synovial macrophage composition and transcriptional profiles in young vs. old joints from male and female mice using single-cell RNA sequencing with cell-surface protein detection (CITE-seq). Results: We defined five major synovial macrophage subpopulations: CX3CR1+ lining, CD163+ interstitial, MHCII+ monocyte-derived, Ly6C+ infiltrating, and Conclusions: In summary, we report on both conserved age-related changes and those that differed between males and females. Our results provide insights on how macrophage heterogeneity changes with age in a sex-dimorphic manner and lays the foundation for research into their role in age-associated diseases, such as arthritis.
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