Evidence map›Paper›PMID 41853273›Full record

ArticleFrontiers in immunology2026

Effectiveness of

Xiao-Tong Huang, Hui Feng, Ye Tan, Quan Wang, Jie-Mei Wei, Zhao-Dong Huang, Xin-Tong Wang, Hai-Jun Lu

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiao-Tong HuangDepartment of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Hui FengDepartment of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Ye TanDepartment of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Quan WangDepartment of Oncology, Qingdao Central Hospital of Rehabilitation University, Qingdao, Shandong, China.
Jie-Mei WeiDepartment of Neurology, Linyi Central Hospital, Linyi, Shandong, China.
Zhao-Dong HuangDepartment of Invasive Technology, Linyi Central Hospital, Linyi, Shandong, China.
Xin-Tong WangDepartment of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Hai-Jun LuDepartment of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Radiation-induced oral mucositis (OM) is a prevalent and debilitating complication of head and neck radiotherapy, yet its severity varies markedly between patients. Emerging evidence suggests that this heterogeneity is influenced by the pre-existing oral microbiome and host inflammatory tone. Methods: This prospective, pragmatic interventional study grouped nasopharyngeal carcinoma (NPC) patients receiving chemoradiotherapy by probiotic exposure: no probiotic, Results: Among 69 evaluable patients, OM occurred in 95.7%, with severe OM (SOM) in 42.4%. Compared with non-probiotic group, SsM18 significantly delayed OM onset ( Conclusions: Radiotherapy-induced OM was associated with baseline oral health and inflammatory status. SsM18 supplementation was associated with improved OM-related outcomes, suggesting a potential role for precision probiotic strategies. Clinical trial information: https://www.chictr.org.cn/, identifier ChiCTR2600118357.

Indexed as

Nasopharyngeal CarcinomaNasopharyngeal NeoplasmsProbioticsRadiation InjuriesStomatitisStreptococcus salivariusAdultAgedFemaleHumansInflammationMaleMiddle AgedProspective StudiesTreatment OutcomeIL-6IL-8inflammationmicrobiotaprobioticsradiation-induced oral mucositisStreptococcus salivarius K12Streptococcus salivarius M18

Identifiers

PMID41853273
PMCPMC12992303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.