Evidence map›Paper›PMID 41853270›Full record

ArticleFrontiers in immunology2026

Polysaccharides from

Zhenhua Yin, Guangyu Hong, Hao Zhang, Juanjuan Zhang, Qingfeng Guo, Kun Li, Li Wang, Lin Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Soluble Dietary Fiber fromInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhenhua YinHenan Engineering Research Center of Chemistry and Biology of Medicinal Resources, Henan Comprehensive Utilization of Edible and Medicinal Plant Resources Engineering Technology Research Center, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Zhengzhou Key Laboratory of Medicinal Resources Research, Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Huanghe Science and Technology College, Zhengzhou, China.
Guangyu HongHenan Engineering Research Center of Chemistry and Biology of Medicinal Resources, Henan Comprehensive Utilization of Edible and Medicinal Plant Resources Engineering Technology Research Center, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Zhengzhou Key Laboratory of Medicinal Resources Research, Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Huanghe Science and Technology College, Zhengzhou, China.
Hao ZhangHenan Engineering Research Center of Chemistry and Biology of Medicinal Resources, Henan Comprehensive Utilization of Edible and Medicinal Plant Resources Engineering Technology Research Center, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Zhengzhou Key Laboratory of Medicinal Resources Research, Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Huanghe Science and Technology College, Zhengzhou, China.
Juanjuan ZhangHenan Engineering Research Center of Chemistry and Biology of Medicinal Resources, Henan Comprehensive Utilization of Edible and Medicinal Plant Resources Engineering Technology Research Center, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Zhengzhou Key Laboratory of Medicinal Resources Research, Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Huanghe Science and Technology College, Zhengzhou, China.
Qingfeng GuoHenan Engineering Research Center of Chemistry and Biology of Medicinal Resources, Henan Comprehensive Utilization of Edible and Medicinal Plant Resources Engineering Technology Research Center, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Zhengzhou Key Laboratory of Medicinal Resources Research, Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Huanghe Science and Technology College, Zhengzhou, China.
Kun LiHenan Engineering Research Center of Chemistry and Biology of Medicinal Resources, Henan Comprehensive Utilization of Edible and Medicinal Plant Resources Engineering Technology Research Center, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Zhengzhou Key Laboratory of Medicinal Resources Research, Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Huanghe Science and Technology College, Zhengzhou, China.
Li WangHenan Engineering Research Center of Chemistry and Biology of Medicinal Resources, Henan Comprehensive Utilization of Edible and Medicinal Plant Resources Engineering Technology Research Center, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Zhengzhou Key Laboratory of Medicinal Resources Research, Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Huanghe Science and Technology College, Zhengzhou, China.
Lin ChenHenan Engineering Research Center of Chemistry and Biology of Medicinal Resources, Henan Comprehensive Utilization of Edible and Medicinal Plant Resources Engineering Technology Research Center, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Zhengzhou Key Laboratory of Medicinal Resources Research, Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Huanghe Science and Technology College, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Although polysaccharides from Methods: In this study, the potential mechanism of PPs in alleviating CTX-induced immunosuppression was investigated by analyzing the gut microbiota, metabolomics, and immune parameters in mice. Results: The results showed that PPs significantly alleviated CTX-induced immunosuppression, as evidenced by increased immune organ indices, improved intestinal mucosalintegrity, elevated serum levels of IL-6 and TNF-α, enhanced activities of ACP, LDH, SOD, and GSH-Px, and reduced MDA content. Western blot analysis indicated that PPs activated the NF-kB and MAPK signaling pathways and upregulated the expression of intestinal tight junction proteins (Claudin-1, Occludin, and ZO-1). Immunohistochemical results further revealed that PPs modulated the numbers of CD4 Discussion: These results suggested that PPs enhanced the immune response in immunocompromised mice by boosting antioxidant capacity, improving the intestinal barrier, modulating gut microbiota structure, and correcting metabolic disturbances.

Indexed as

Gastrointestinal MicrobiomeImmune TolerancePolysaccharidesPsoraleaAnimalsIntestinal MucosaMaleMetabolomicsMiceSignal TransductionPolysaccharidesgut microbiotaimmune signalingimmunoregulationmetabonomicspolysaccharides from Psoralea corylifolia L.

Identifiers

PMID41853270
PMCPMC12992029

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.