Evidence map›Paper›PMID 41853231›Full record

ReviewADMET & DMPK2026

Rosanoid diterpenoids: structural diversity, classification and biological activities.

Sabrin R M Ibrahim, Hani Z Asfour, Gamal A Mohamed, Nabil A Alhakamy, Hossam M Abdallah, Hagar M Mohamed

Abstract readReview
In one paragraph

Review in ADMET & DMPK, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sabrin R M IbrahimPreparatory Year Program, Department of Chemistry, Batterjee Medical College, Jeddah 21442, Saudi Arabia.ORCID 0000-0002-6858-7560
Hani Z AsfourDepartment of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0009-0000-5123-5879
Gamal A MohamedDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-2971-6008
Nabil A AlhakamyDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-3826-1519
Hossam M AbdallahDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-0234-7492
Hagar M MohamedDepartment of Medical Laboratory Analysis, College of Medical & Health Sciences, Liwa University, Abu Dhabi 41009, United Arab of Emirates.ORCID 0000-0002-6553-7840

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Rosanoid diterpenoids, including ent-rosane and rosane diterpenoids, are structurally unique and bioactive subclass diterpenes characterized by a tricyclic carbon skeleton. This work aims to provide a comprehensive review of the literature on these diterpenoids from 1975. to September 2025., including their occurrence, structural diversity, and biological activities. Approach: An extensive literature search was conducted through scientific databases (ScienceDirect, PubMed, Scopus, Web of Science, and Google Scholar) and publishers' webpages (Elsevier, Wiley, ACS, RSC, Taylor & Francis, Springer, Bentham, Thieme, and MDPI), covering reports from 1975 to September 2025. Key Results: Rosanoid diterpenoids have been isolated from various natural sources, including fungi, liverworts, and higher plant families such as Conclusion: The reported findings highlight the chemical variability and pharmacological potential of rosanoid diterpenoids, making them promising building blocks for future drug discovery and natural product development. However, further studies are warranted to explore their pharmacokinetics, mechanisms of action, safety profiles, and biosynthetic pathways.

Indexed as

drug discoveryent-rosane diterpenoidsEuphorbiaceaenatural productsrosane diterpenoidsustainable development

Identifiers

PMID41853231
PMCPMC12994591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.