ArticleACS applied nano materials2026
Calixarene-Based Nanostructures for Delivering Coumarin 6 for Tumor-Cell Imaging and Photoinduced Toxicity.
Article in ACS applied nano materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Coumarin and Curcumin-Metal Complexes as Next-Generation Photosensitizers in Cancer Photodynamic Therapy.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescence imaging techniques are emerging as safer and more sensitive alternatives to radionuclide-based approaches for cancer diagnosis. Entrapping fluorophores that also act as photosensitizers within nanocarriers is an effective strategy to enhance their stability, performance, and selective delivery to tumor tissues, enabling the development of advanced nanosystems for cancer cell imaging and theranostic applications. In this work, we report a fluorescent nanosystem obtained by entrapping Coumarin 6 in biocompatible nanostructures formed through the self-assembly of an amphiphilic calix[4]-arene derivative functionalized with choline ligands for targeting tumor cells. The nanosystem was characterized using diverse techniques, which confirmed nanoscale organization, colloidal stability, excellent resistance to freeze-drying, good fluorescence quantum yield, and visible-light-triggered photodynamic activity, as evidenced by methylene blue photodegradation. Molecular modeling simulations provided mechanistic insight into the host-guest interactions governing Coumarin 6 stabilization in the nanocarrier. The nanosystem selectively imaged breast carcinoma (MCF-7 and MDA-MB-231) and hepatocarcinoma (Hep3B and SNU398) cells that overexpress the choline transporter, while negligible uptake was observed in nonmalignant human fibroblasts (HuDe cells). Intracellular fluorescence intensity correlated with choline transporter expression levels, and the competitive inhibition assay supported a transporter-mediated cellular uptake mechanism. Upon biocompatible visible-light irradiation, the nanosystem effectively induced cancer cell death through activation of the Coumarin 6 photosensitizer. The integration of targeted cancer cell imaging and phototriggered cytotoxicity highlights this fluorescent nanosystem as a promising photoresponsive nanotheranostic candidate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.