Evidence map›Paper›PMID 41853143›Full record

ArticleFrontiers in genetics2026

Defects in

Yuquan Lu, Jiangjie Liu, Siyu Sun, Zhiyu Feng, Yuan Gao, Shaojie Min, Quannan Zhuang, Siyi Lin, Quming Zhao, Xianghui Huang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuquan LuPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Jiangjie LiuPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Siyu SunPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Zhiyu FengPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Yuan GaoPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Shaojie MinPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Quannan ZhuangPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Siyi LinPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Quming ZhaoPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Xianghui HuangFujian Key Laboratory of Neonatal Diseases, Xiamen Children's Hospital, Xiamen, Fujian, China.
Wei ShengPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Guoying HuangPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Congenital heart disease (CHD) comprises structural abnormalities of the heart and major blood vessels arising during fetal development. Protein disulfide isomerase family member 4 (PDIA4) facilitates protein folding processes. However, its potential involvement in CHD has not been investigated. In this study, we identified Methods: Whole-exome sequencing and targeted sequencing were performed to identify Results: A Conclusion: Our study suggests that

Indexed as

congenital heart diseaseprotein disulfide isomerase family member 4targeted sequencingvariantswhole-exome sequencingwnt/β-catenin signaling pathway

Identifiers

PMID41853143
PMCPMC12995189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.