Evidence map›Paper›PMID 41853116›Full record

ArticleASM case reports2026

Clearance of hypermutator XDR

Viseth Ngauy, Scott Bevans, Donna Kido, Rachel Ibrahimovic, Edwin Kamau, Angela Caldwell, Robert Pangilinan, Roy Levit, Francois Lebreton, Andrey A Filippov and 4 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ASM case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Viseth NgauyInfectious Disease Service, Department of Medicine, Tripler Army Medical Center, Honolulu, Hawaii, USA.ORCID https://orcid.org/0009-0001-8239-3543
Scott BevansHead and Neck Oncology, Otolaryngology Service, Tripler Army Medical Center, Honolulu, Hawaii, USA.
Donna KidoDepartment of Pharmacy, Tripler Army Medical Center, Honolulu, Hawaii, USA.
Rachel IbrahimovicDepartment of Pharmacy, Tripler Army Medical Center, Honolulu, Hawaii, USA.
Edwin KamauDepartment of Pathology and Area Laboratory Services, Tripler Army Medical Center, Honolulu, Hawaii, USA.ORCID https://orcid.org/0000-0002-5761-7883
Angela CaldwellDepartment of Pathology and Area Laboratory Services, Tripler Army Medical Center, Honolulu, Hawaii, USA.
Robert PangilinanDepartment of Medicine, Tripler Army Medical Center, Honolulu, Hawaii, USA.
Roy LevitInternal Medicine Residency Program, Department of Medicine, Tripler Army Medical Center, Honolulu, Hawaii, USA.
Francois LebretonMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Diagnostics and Countermeasures Branch, Center for Infectious Diseases Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID https://orcid.org/0000-0002-7157-5026
Andrey A FilippovWound Infections Department, Bacterial Diseases Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID https://orcid.org/0000-0003-2256-861X
Ting L LuoMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Diagnostics and Countermeasures Branch, Center for Infectious Diseases Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Damon W EllisonBacterial Diseases Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Mikeljon P NikolichWound Infections Department, Bacterial Diseases Branch, CIDR, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID https://orcid.org/0000-0001-5770-8980
Patrick McGannMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Diagnostics and Countermeasures Branch, Center for Infectious Diseases Research (CIDR), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID https://orcid.org/0000-0003-1548-9438

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bacteriophages (phages), viruses ubiquitous in the environment infecting bacteria, are an increasingly attractive option for adjunct therapy with conventional antibiotics in complicated, refractory multidrug-resistant infections. Bacteria ("hypermutators") with defects in methyl-directed mismatch repair (MMR) have been described in Case Summary: A 72-year-old male with mild chronic obstructive pulmonary disease, diagnosed with resectable, advanced right frontoethmoid adenoid cystic carcinoma, underwent endoscopic resection to remove the affected bone and tissue. The subsequent large craniofacial defect was reconstructed with non-vascularized calvarial bone grafts, rigidly fixated with titanium hardware and externally covered with a vascularized pericranial flap. He developed complete dehiscence of the skull base reconstruction, and wound cultures grew multiple susceptible Conclusion: This case suggests that phage therapy may be useful in the treatment of deep-seated hypermutator

Indexed as

hypermutatorphage therapyPseudomonas aeruginosa

Identifiers

PMID41853116
PMCPMC12955376

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.