Evidence map›Paper›PMID 41853115›Full record

ArticleASM case reports2026

Acquisition of bedaquiline and clofazimine resistance in association with a novel loss-of-function mutation in the

Melissa Richard-Greenblatt, Ruchika Bagga, Carla Duncan, Maxime J Billick, Howard Song, Natasha F Sabur, Vincent Escuyer, Karen Lam, Sarah K Brode

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ASM case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.International journal of molecular sciences · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Melissa Richard-GreenblattPublic Health Ontario, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-6717-8856
Ruchika BaggaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-1279-1738
Carla DuncanPublic Health Ontario, Toronto, Ontario, Canada.
Maxime J BillickDepartment of Infectious Diseases, University of Toronto, Ontario, Canada.
Howard SongUniversity Health Network, Toronto, Ontario, Canada.
Natasha F SaburUniversity Health Network, Toronto, Ontario, Canada.
Vincent EscuyerWadsworth Centre, New York State Department of Health, Albany, New York, USA.
Karen LamPublic Health Ontario, Toronto, Ontario, Canada.
Sarah K BrodeUniversity Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-3855-6368

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bedaquiline (BDQ) has transformed the management of multidrug-resistant (MDR) and rifampin-resistant tuberculosis (TB). Unfortunately, the expanded use of BDQ in these regimens has been accompanied by resistance, which is steadily increasing in certain regions of the world. Nonetheless, our understanding of the mechanisms behind BDQ resistance remains poor, limiting the utility of more rapid molecular or genomic-based diagnostics for the detection of BDQ-resistant isolates. Case Summary: We describe an unusual case of a rapid, 2-year evolution of a fully susceptible Conclusion: This case contributes to the limited clinical data implicating

Indexed as

bedaquiline resistanceCanadaclofazimine resistanceMDR/RR-TBpepQtuberculosisXDR-TB

Identifiers

PMID41853115
PMCPMC12955440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.