Evidence map›Paper›PMID 41853066›Full record

ArticleNeurobiology of stress2026

Corticotropin releasing hormone-expressing inputs to the thalamic paraventricular nucleus: pathways from mother to memory?

Jorge M Mendoza, Amalia Floriou-Servou, Yuncai Chen, Cassandra Kooiker, Mason Hardy, Tallie Z Baram

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jorge M MendozaDepartment of Anatomy and Neurobiology, University of California-Irvine, Irvine, CA, USA.
Amalia Floriou-ServouDepartment of Anatomy and Neurobiology, University of California-Irvine, Irvine, CA, USA.
Yuncai ChenDepartment of Anatomy and Neurobiology, University of California-Irvine, Irvine, CA, USA.
Cassandra KooikerDepartment of Anatomy and Neurobiology, University of California-Irvine, Irvine, CA, USA.
Mason HardyDepartment of Anatomy and Neurobiology, University of California-Irvine, Irvine, CA, USA.
Tallie Z BaramDepartment of Anatomy and Neurobiology, University of California-Irvine, Irvine, CA, USA.

Funding

Structural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 2013 to 2023
$25.4M
Epilepsy Research Training ProgramT32NS045540 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, Robert F Hunt · 2003 to 2026
$4.9M
On circuit mechanisms of reward behaviors after early-life adversityRF1MH132680 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z., CHEN, YUNCAI · 2025 to 2025
$2.1M
On circuit mechanisms of reward behaviors after early-life adversityR01MH132680 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z., CHEN, YUNCAI · 2023 to 2024
$1.3M
NIMH NIH HHS P50 MH096889NIMH NIH HHS R01 MH132680NIMH NIH HHS RF1 MH132680NINDS NIH HHS T32 NS045540
6 · The paper itself

Abstract

Thalamic paraventricular nucleus (PVT) neurons expressing the corticotropin releasing hormone receptor 1 (CRHR1) are preferentially activated during early life stress. However, it is unclear how the receptor ligand, the stress-related peptide CRH, reaches receptor-bearing cells. To address this question, we mapped local, proximal and distal sources of CRH, i.e., CRH expressing neurons within, adjacent to and projecting to PVT. The combined use of retrograde and anterograde viral-genetic tracing approaches, validated with immunohistochemistry, identified an array of CRH neurons within PVT, in the adjacent paratenial nucleus as well as projecting to PVT from the parabrachial and Barrington nuclei. The latter are poised to convey to the PVT sensory signals from maternal grooming, as envisioned by Seymour Levine in the 1950s.

Indexed as

AAV viral tracingBarrington nucleusCorticotropin-releasing hormoneCorticotropin-releasing hormone receptor 1Parabrachial nucleiParatenial nucleusThalamic paraventricular nucleus

Identifiers

PMID41853066
PMCPMC12994073

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.