Evidence map›Paper›PMID 41853044›Full record

ArticleBrain communications2026

Ventricular enlargement is associated with early Alzheimer's disease pathophysiology.

Seyyed Ali Hosseini, Etienne Aumont, Nesrine Rahmouni, Marcel S Woo, Arthur C Macedo, Brandon Hall, Lydia Trudel, Tevy Chan, Jaime Fernandez Arias, Yi-Ting Wang and 32 more

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Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Seyyed Ali HosseiniTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Etienne AumontTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Nesrine RahmouniTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Marcel S WooTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.ORCID https://orcid.org/0000-0002-1306-2708
Arthur C MacedoTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Brandon HallTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Lydia TrudelTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.ORCID https://orcid.org/0009-0002-5593-7717
Tevy ChanTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Jaime Fernandez AriasTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.ORCID https://orcid.org/0000-0002-6810-5920
Yi-Ting WangTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Stijn ServaesTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Joseph TherriaultTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.ORCID https://orcid.org/0000-0002-7826-4781
Yansheng ZhengTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Kely Quispialaya SocualayaTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Gleb BezginTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Cécile TissotDepartment of Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID https://orcid.org/0000-0003-2711-3833
Delphine Oliva-LopezTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Robert HopewellTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Chris Hung-Hsin HsiaoDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.
Catherine SalehDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.
Jenna StevensonThe McGill University Research Center for Studies in Aging, Douglas Mental Health Institute, Montreal, Quebec H4H 1R3, Canada.
Firoza LussierDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Liyong WuTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Min ChuTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Sanjeev ChawlaDepartment of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0001-6978-7284
Vladimir FonovDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.ORCID https://orcid.org/0000-0003-3402-7749
Gassan MassarwehDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.
Yasser Iturria-MedinaDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.
Jean-Paul SoucyDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.
David A RudkoDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.ORCID https://orcid.org/0000-0002-1299-954X
Serge GauthierDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.
Thomas KarikariDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID https://orcid.org/0000-0003-1422-4358
Andréa Lessa BenedetDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal 413 45, Sweden.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal 413 45, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal 413 45, Sweden.
Maxime MontembeaultThe McGill University Research Center for Studies in Aging, Douglas Mental Health Institute, Montreal, Quebec H4H 1R3, Canada.
Paolo VitaliDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.ORCID https://orcid.org/0000-0001-8953-1542
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal 413 45, Sweden.
D Louis CollinsDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada.ORCID https://orcid.org/0000-0002-8432-7021
Jesse KlostranecDepartment of Diagnostic and Interventional Neuroradiology, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada.
Tharick A PascoalDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.ORCID https://orcid.org/0000-0001-9116-1376

Funding

Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in bloodR01AG083874 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas K Karikari · 2023 to 2026
$14.5M
NIA NIH HHS R01 AG083874
6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by progressive brain changes, including protein aggregation and structural changes. Cerebrospinal fluid (CSF) system abnormalities, such as ventricular dilation, increased choroid plexus volume or positron emission tomography (PET) ligand uptake in the CSF, have also been consistently described. We aimed to examine whether changes in CSF production and clearance might be associated with brain protein aggregation across biological stages of Alzheimer's disease. We hypothesized an association between brain protein aggregation and changes on the CSF system. We examined 378 individuals from the Translational Biomarkers in Aging and Dementia (TRIAD) cohort with T1-weighted magnetic resonance imaging (MRI), amyloid-PET and tau-PET assessments. We assessed the lateral ventricle and choroid plexus volumes, both corrected for intracranial volume, in the MRI native space. Non-specific ventricular tracer standardized uptake value ratio (SUVR), derived from amyloid- and tau-PET images, was used as an indirect marker of choroid plexus-related clearance activity and served as a metric of CSF dynamics. Linear models tested associations amongst lateral ventricular volume (reflecting CSF space enlargement), choroid plexus volume (reflecting secretory tissue morphology) and ventricular SUVR (reflecting tracer activity within the CSF compartment and serving as an indirect marker of choroid plexus-related clearance function and CSF dynamics) with Aβ and tau aggregations. Analyses were restricted to within-modality associations, relating ventricular radioactivity to cortical pathology for each PET tracer. We found that when considered independently, larger ventricular and choroid plexus volumes were associated with higher neocortical Aβ-PET SUVR, particularly in the precuneus and cingulate cortices. Additionally, lower ventricular radioactivity (derived from amyloid-PET) showed strong negative associations in the dorsal apex of the neocortex. However, when all three ventricular parameters were included in the same model, these effects were mediated by ventricular volume. By contrast, the effect of the ventricular parameters on tau load was mediated by Aβ in the neocortex. Therefore, ventricular enlargement appears to be associated with Aβ load. Distinct from neurodegeneration, changes in ventricular parameters, particularly ventricular volume, are associated with upstream Alzheimer's disease pathophysiology. While ventricular volume significantly mediated ventricular amyloid clearance, no such effect was observed for tau, suggesting distinct clearance mechanisms for these pathologies in Alzheimer's disease.

Indexed as

Alzheimer’s diseasechoroid plexusCSF clearanceprotein aggregationventricular enlargement

Identifiers

PMID41853044
PMCPMC12993450

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.