ArticleJournal of pharmacy & bioallied sciences2026
A Systematic Review on a Variety of Alternate Fluoride Options Effective in Preventing Dental Caries.
Article in Journal of pharmacy & bioallied sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional fluoride therapies are effective in preventing dental caries but present limitations, such as esthetic concerns and fluoride sensitivity This has led to the development of alternate agents with comparable or improved preventive potential. To systematically review and evaluate the effectiveness of alternate fluoride-based and fluoride-free interventions in the guidelines. A prevention of dental caries. This review adhered to PRISMA 2020 comprehensive literature search was conducted across five databases and grey literature sources. Studies included randomized controlled trials, in vitro experiments, and systematic reviews without meta-analysis that examined the efficacy of agents, such as "silver diamine fluoride (SDF)," "nano-silver fluoride (NSF)," grape seed extract, hydroxyapatite, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), probiotics, and bioactive glasses Data were extracted regarding intervention type, mechanism, outcomes, and patient acceptability. Twenty studies met inclusion criteria. SDF was found to be noninferior to conventional sealants, while NSF offered superior esthetic outcomes with better caries arrest. Hydroxyapatite, CPP-ACP, and bioactive glasses demonstrated significant remineralization potential. Natural agents, such as theobromine and grape seed extract, showed antimicrobial and surface hardening benefits. Probiotics effectively reduced cariogenic bacterial load. Alternative caries-preventive strategies, especially NSF, CPP-ACP, and natural agents, demonstrate strong potential. Further long-term clinical trials are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.