ArticleJournal of pharmacy & bioallied sciences2026
Regenerative Endodontics and Stem Cell-Based Therapies - A Systematic Review.
Article in Journal of pharmacy & bioallied sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional root canal treatment removes the infection successfully, but the vitality of pulp-dentin complex cannot be restored. The birth of regenerative endodontics is a biologically driven technique that seeks to restore pulp vitality, coax the root into forming, and maintain long-term functionality of the tooth. This review critically appraises the available evidence regarding regenerative endodontics and stem cell-based therapies in clinical practice. PRISMA guidelines were adopted for a comprehensive search of the literature in PubMed, Scopus, Web of Science, Cochrane Library, and Embase. Human trials reporting cellular transplantation-based or cell-homing regenerative approaches were considered. Five eligible human studies were included. Stem cell sources comprised dental pulp stem cells and stem cells from human exfoliated deciduous teeth, while platelet concentrates and collagen scaffolds were commonly used. Clinical outcomes included restoration of pulp vitality, apical closure, dentin wall thickening, and periapical healing, with no major adverse events reported. Stem cell-based regenerative endodontics demonstrates promising clinical potential but remains constrained by small sample sizes, protocol heterogeneity, and limited follow-up. Standardized methodologies and long-term randomized controlled trials are needed before integration into routine practice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.