ArticleJournal of pharmacy & bioallied sciences2026
Analysis of Salivary Levels of Titanium and Nickel Levels among Patients Treated with Dental Implants Therapy.
Article in Journal of pharmacy & bioallied sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: The present investigation aimed to evaluate salivary concentrations of titanium and nickel in individuals subjected to endosseous implant therapy. Materials and Methods: A total cohort of 100 participants was recruited. Among them, 50 individuals constituted the control cohort without prosthetic intervention, whereas the remaining 50 individuals had undergone placement of a single osseointegrated implant fixture. Unstimulated whole saliva samples were collected from each subject and subsequently analyzed for trace metal quantification of titanium and nickel. The recorded data were systematically tabulated, and statistical interpretation was performed utilizing SPSS analytical software. Results: The study group comprised 69 male and 31 female participants. Subjects rehabilitated with dental implants demonstrated mean salivary titanium concentration of 123.54 ± 258.02 μg/L and mean salivary nickel concentration of 53.97 ± 16.09 μg/L. In comparison, the control cohort without implant placement exhibited relatively diminished levels of both metallic ions. Conclusion: The outcomes of this investigation indicate that salivary titanium and nickel concentrations are significantly elevated in patients treated with endosseous dental implants compared to individuals without such prosthetic rehabilitation.
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