ArticleJournal of pharmacy & bioallied sciences2026
Vitamin D Levels in Serum and Aqueous Humor of Cataract Patients With and Without Diabetes.
Article in Journal of pharmacy & bioallied sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Vitamin D plays an essential role in systemic and ocular health, with deficiency potentially contributing to cataractogenesis and diabetic eye disease. Although serum vitamin D levels have been extensively studied, limited data exist on its concentration in the aqueous humor. This study aimed to estimate and compare vitamin D levels in serum and aqueous humor of cataract patients with and without diabetes mellitus (DM) and to assess the influence of vitamin D supplementation. Materials and Methods: A cross-sectional observational study was conducted from September 2022 to July 2024 at Shyam Shah Medical College and Gandhi Memorial Hospital, Rewa. A total of 400 senile cataract patients were enrolled, categorized into diabetic (n = 148) and nondiabetic (n = 252) groups. Patients with ocular comorbidities or prior ocular interventions were excluded. Detailed history and relevant investigations were recorded. During small incision cataract surgery (SICS), aqueous humor and serum samples were collected. Total 25-hydroxyvitamin D concentrations were measured using Electrochemiluminescence Competitive Immunoassay. Results: Age, sex, and vitamin D supplementation status were comparable between diabetic and nondiabetic groups. Serum and aqueous humor vitamin D levels did not differ significantly between groups ( Conclusion: No significant differences in serum or aqueous vitamin D levels were observed between diabetic and nondiabetic cataract patients. Vitamin D supplementation did not significantly affect these levels, suggesting a possible shared deficiency profile. Further research is warranted to explore the ocular implications of vitamin D status.
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