Reduced circulating progenitor cells in older adults with major depression: Evidence of accelerated biological aging.

Erica L Vieira, Perla El-Ahmad, Yuliya Nikolova, Tarek Rajji, Breno S Diniz

Abstract read

In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erica L VieiraCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Perla El-AhmadUConn Center on Aging & Department of Psychiatry, UConn School of Medicine, University of Connecticut Health Center, Farmington, CT, USA.

Yuliya NikolovaCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Tarek RajjiDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Breno S DinizUConn Center on Aging & Department of Psychiatry, UConn School of Medicine, University of Connecticut Health Center, Farmington, CT, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major depression (or late-life depression [LLD]) is a prevalent and debilitating condition among older adults and is increasingly recognized as a contributor to accelerated biological aging. LLD has been associated with aging-related phenotypes, namely chronic inflammation and cellular senescence. However, stem and progenitor cell exhaustion, another pivotal hallmark of biological aging, remains understudied in this context. In this study, we investigated the absolute count and frequency of circulating progenitor cell populations in peripheral blood mononuclear cells (PBMC) of 38 older adults (LLD, n = 19; control, n = 19). CD34

Indexed as

AgingCirculating progenitor cellsEPCLate life depressionvSELs

Identifiers

PMID41852949

DOI10.1016/j.bbih.2026.101211

PMCPMC12993884

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.