ArticleNew microbes and new infections2026
Amikacin exposure in MDR-TB patients in Uganda: Revisiting old drugs in a new era of resistance - A pharmacokinetic assessment.
Article in New microbes and new infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Amid rising resistance to bedaquiline, aminoglycosides remain an important fallback option for multidrug-resistant tuberculosis (MDR-TB) treatment, particularly in high-burden settings. Their use is limited by nephro- and ototoxicity, which is associated with cumulative drug exposure. In this study we investigated amikacin exposure in Ugandan MDR-TB patients using a validated limited sampling strategy and compared the results to previously published data from a Western European cohort. Methods: In this single-centre prospective observational study, 29 MDR-TB patients received amikacin at a dose of 10-15 mg/kg. Serum levels were measured on day 30 at 1, 4 and 5 h post-administration using liquid chromatography/mass spectrometry. Individual concentration-time curves were modelled using a one-compartment model and compared to a Dutch population-pharmacokinetic (PK) model. Results: Twenty patients had complete PK data. Patients received a median amikacin dose of 10.9 (IQR 10 - 14.9) mg/kg; clearance was 4.79 L/h (IQR 4.03 - 5.75), volume of distribution (Vd) 16.3 L (IQR 14.07 - 21.49), AUC Conclusions: This population-PK study shows that major differences in PK between Ugandan MDR-TB patients and those in the Global North are unlikely. Our findings reinforce the suitability of a one-compartment model for therapeutic drug monitoring in both high- and low-resource settings. Readily obtained aminoglycoside PK parameters in a limited resource setting facilitate future efforts in optimizing drug exposure with minimal toxicities, in the population most affected by the pandemic of TB.
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