ArticleMaterials today. Bio2026
A glycopeptide hydrogel confers protection and treatment in sepsis via recruitment and training of macrophages.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Sepsis is a critical global health challenge, characterized by dysregulated host responses and high mortality rates. Current treatment therapies inadequately address persistent immunoparalysis and adverse reactions, leaving survivors susceptible to recurrent infections. Herein, we developed the first β-glucan (BG) delivery system using self-assembling peptide hydrogels to combat immuneparalysis associated with sepsis. This hydrogel combines oxidized BG (BGA) and tuftsin-functionalized self-assembling peptides (t-RADA16) to create an injectable glycopeptide hydrogel (BGA@t-RADA16). Upon subcutaneous injection, the hydrogel forms a dual-functional platform consisting of a "sustained-release depot" of BGA and a local "trained immunity center", where the three-dimensional network of peptide nanofibers actively recruits macrophages and the BGA educates them
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