Evidence map›Paper›PMID 41852835›Full record

ArticleEuropean heart journal. Imaging methods and practice2026

Evaluating biventricular diastolic function using cardiovascular magnetic resonance 4d-flow derived E/e'.

Leonard Grob, Jacopo Soldini, Stephanie Keser, Davide Colatruglio, Louis Setz, Anna C Zimmermann, Dario Kaiser, Bernd Jung, Adrian T Huber, Hendrik von Tengg-Kobligk and 5 more

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In one paragraph

Article in European heart journal. Imaging methods and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Leonard GrobDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, Bern 3010, Switzerland.
Jacopo SoldiniDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, Bern 3010, Switzerland.
Stephanie KeserDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, Bern 3010, Switzerland.
Davide ColatruglioDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, Bern 3010, Switzerland.
Louis SetzDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, Bern 3010, Switzerland.
Anna C ZimmermannDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, Bern 3010, Switzerland.
Dario KaiserDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, Bern 3010, Switzerland.
Bernd JungDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Adrian T HuberDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Hendrik von Tengg-KobligkDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Martina Boscolo BertoDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Matthias WilhelmDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-0032-0181
Christoph GräniDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0001-6029-0597
Dominik P GuenschDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, Bern 3010, Switzerland.ORCID https://orcid.org/0000-0003-4127-4086
Kady FischerDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, Bern 3010, Switzerland.ORCID https://orcid.org/0000-0002-7765-4550

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Cardiovascular magnetic resonance (CMR) imaging is a key modality for characterizing heart diseases, but is limited in assessing diastolic dysfunction (DD). 4D flow CMR now enables transvalvular blood flow quantification, while biventricular tissue relaxation can be quantified through annular tissue velocity and strain on standard cine images. This study investigated the utility of 4D-CMR-derived E/e' in evaluating biventricular diastolic function. Secondary aims included comparison with echocardiography to establish 4D-E/e' cutoffs for detecting unknown DD. Methods and results: Diastolic transvalvular flow (4D-E) was quantified from 4D flow in 75 controls and 57 patients with cardiovascular disease. Tissue velocity (e') was assessed using cine-derived mitral/tricuspid annular velocity, longitudinal strain rate (e' Conclusion: 4D-E/e', integrating transvalvular flow and tissue velocity, is feasible for biventricular diastolic function assessment. CMR identified previously unrecognized biventricular diastolic abnormalities in patients with cardiovascular disease, suggesting 4D-E/e' may be a valuable tool for early detection and referral for further diastolic testing.

Indexed as

4D flowcardiovascular magnetic resonancediastolic dysfunctione/e’myocardial strainright ventricle

Identifiers

PMID41852835
PMCPMC12994140

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.