ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2026
Thymol modulates rumen barrier function and inflammation in feed-restricted lambs.
Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Thymol, with antimicrobial, antioxidative, and anti-inflammatory properties, shows promise in improving epithelial barrier function and reducing inflammation. This study investigated whether thymol could alleviate the detrimental impacts of severe feed restriction (SFR) on barrier function by its effects on inflammatory signaling pathways and tight junction (TJ) protein expression. Thirty Baluchi ram lambs (45.2 ± 6.2 kg; 8 months of age) were randomly allocated to three groups: control (CON), SFR, and SFR plus thymol (SFRT), with 10 lambs per group serving as experimental replicates. The experiment consisted of four weeks of feed restriction (FR) followed by four weeks of ad libitum feeding (Ad-L). Thymol (300 mg/d per lamb) was orally administered to SFRT group during the FR period. Growth performance, ruminal fermentation parameters, plasma metabolites, and inflammatory biomarkers were assessed. Histological measurements of the rumen tissue, as well as mRNA expressions of TJ proteins and proinflammatory cytokines in the rumen epithelium were analyzed. Compared with CON, the final body weight of lambs significantly decreased during FR in SFRT and SFR groups (
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