Evidence map›Paper›PMID 41852831›Full record

ArticleFrontiers in oral health2026

Association between periodontitis, leukoaraiosis and sTWEAK. A case-control study.

Jorge Moldes, Antonio Arnau, Manuel Rodríguez-Yáñez, Iria López-Dequidt, Pablo Hervella, Juan Blanco, Ramón Iglesias-Rey, Tomás Sobrino, Yago Leira

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Article in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jorge MoldesFamily and Community Medicine Department, Bueu Health Centre, Pontevedra University Clinical Hospital, Pontevedra, Spain.
Antonio ArnauPeriodontology Unit, Faculty of Odontology and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.
Manuel Rodríguez-YáñezStroke Unit, Neurology Department, University Clinical Hospital, Santiago de Compostela, Spain.
Iria López-DequidtStroke Unit, Neurology Department, University Clinical Hospital, A Coruña, Spain.
Pablo HervellaNeuroimaging and Biotechnology Laboratory (NOBEL) Group, Clinical Neurosciences Research Laboratories, Health Research Institute of Santiago de Compostela, University Clinical Hospital, Santiago de Compostela, Spain.
Juan BlancoPeriodontology Unit, Faculty of Odontology and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.
Ramón Iglesias-ReyNeuroimaging and Biotechnology Laboratory (NOBEL) Group, Clinical Neurosciences Research Laboratories, Health Research Institute of Santiago de Compostela, University Clinical Hospital, Santiago de Compostela, Spain.
Tomás SobrinoNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, Madrid, Spain.
Yago LeiraPeriodontology Unit, Faculty of Odontology and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In recent years, periodontitis has been associated with various systemic diseases, including neurological pathology, and systemic inflammation has been proposed as a potential link. The aim of this study was to investigate the relationship between periodontitis and the presence of leukoaraiosis (LA). The contribution of periodontitis to serum levels of soluble fragment of tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) in LA was also explored. Methods: We performed a nested case-control study including patients with LA ( Results: Both the prevalence of periodontitis and mean serum sTWEAK concentrations were significantly higher in LA patients than controls (74.3% vs. 32.1%, Conclusions: Periodontitis may be associated with the presence of LA and when present it could contribute to elevated serum levels of sTWEAK.

Indexed as

cerebral small vessel diseaseleukoaraiosisneurologyperiodontitisrisksTWEAK

Identifiers

PMID41852831
PMCPMC12992221

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.