Behavioromics: A New Paradigm of Big Data-Powered Insights for Proactive Health.

Behavior plays a critical role in health and disease. Although molecular omics have advanced the understanding of biological mechanisms, they alone cannot explain the role of behavior in health, and traditional behavioral measurement technologies have struggled to capture the dynamic, multidimensional, and heterogeneous nature of real-world behaviors. With the development of digital technologies such as wearable devices, smartphone sensors, and ecological momentary assessment, behavioromics has emerged as a new research paradigm with a holistic systems perspective, integrating continuous, multimodal behavioral data with molecular, physiological, and environmental information. By organizing behavioral measurement, modeling, and interpretation within a unified analytical framework, behavioromics reveals dynamic behavioral patterns, supports mechanism-informed inference, and identifies actionable targets for early intervention. Despite ongoing challenges in data heterogeneity, causal interpretation, and ethical governance, behavioromics holds promise for reshaping disease prediction, early detection, and precision intervention, and for advancing proactive health through earlier, behavior-centered prevention.