Evidence map›Paper›PMID 41852791›Full record

ArticleDrug and alcohol dependence reports2026

Monday mood decline after weekend ecstasy use: A retrospective analysis of daily diary reports.

Christopher Medina-Kirchner, Scott E Lukas

Abstract read
In one paragraph

Article in Drug and alcohol dependence reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher Medina-KirchnerDepartment of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.
Scott E LukasDepartment of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ecstasy is commonly used on weekends and linked to post-use mood declines. Laboratory studies with pure MDMA rarely detect residual effects, whereas naturalistic studies more often report mood reductions. The timing and contextual drivers of these effects remain unclear. Methods: Data from seventeen participants reporting weekend ecstasy use (10 male, 7 female; 19-38 years) were drawn from a previously conducted study and analyzed for temporal mood changes not identified in the original report. Participants completed observation weeks following both ecstasy-use and nonuse weekends. Daily diaries assessed mood (0-10), other affective states, drug use, and sleep-related measures. Weekly BDI-II and BAI scores were collected. Results: A significant Weekend Ecstasy X Day interaction was present ( Conclusions: Residual mood effects appear Monday-specific and are attenuated when inactivity is considered, suggesting recovery-related behavior-not MDMA alone-may underlie post-use mood declines. Because increased time in bed may both reflect and influence low mood, directionality cannot be determined.

Indexed as

Daily diaryEcstasyMDMAMoodNaturalistic study

Identifiers

PMID41852791
PMCPMC12993375

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.