Evidence map›Paper›PMID 41852774›Full record

ArticleOsteoarthritis and cartilage open2026

CSPG4

Xin Zhang, Lindsey Adair MacFarlane, Janet L Huebner, Jason Jinkun Tao, Jeffrey Neil Katz, Virginia Byers Kraus

Abstract read
In one paragraph

Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xin ZhangDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Lindsey Adair MacFarlaneOrthopedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Janet L HuebnerDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Jason Jinkun TaoDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Jeffrey Neil KatzOrthopedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Virginia Byers KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.

Funding

Extracellular Vesicle Analyses to Develop Aging and Resilience BiomarkersR01AG070146 · NIA · DUKE UNIVERSITY · PI KRAUS, VIRGINIA B · 2021 to 2025
$3.1M
NIA NIH HHS R01 AG070146
6 · The paper itself

Abstract

Objectives: To evaluate chondroitin sulfate proteoglycan 4 (CSPG4) Methods: Radiographic and symptomatic OA severity were evaluated in participants from two separate institutions. EVs were isolated from plasma (discovery cohort, n = 51; validation cohort, n = 92) and synovial fluid (SF) (n = 61) from 204 OA patients and characterized by morphology, surface markers, and pathogenic cargo, and evaluated for associations with knee OA severity. Single-cell RNA sequencing datasets (GSE152805 and GSE216651) were used to elucidate the joint tissue localization of the genes of interest. Results: Across both discovery and validation cohorts, plasma CSPG4 Conclusions: We identified CSPG4

Indexed as

CSPG4Extracellular vesicleFibronectinKnee osteoarthritisPlasmaSynovial fluid

Identifiers

PMID41852774
PMCPMC12992086

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.