Evidence map›Paper›PMID 41852772›Full record

ArticleOsteoarthritis and cartilage open2026

Increase in knee-adjacent subcutaneous fat is associated with cartilage degeneration independent of BMI: A four-year analysis of the OAI dataset.

Gabby B Joseph, Charles E McCulloch, Felix Liu, John A Lynch, Sharmila Majumdar, Nancy E Lane, Michael C Nevitt, Thomas M Link

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabby B JosephDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA.
Felix LiuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA.
John A LynchDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA.
Sharmila MajumdarDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA.
Nancy E LaneDepartment of Rheumatology, University of California, Davis, USA.
Michael C NevittDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA.
Thomas M LinkDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To determine whether changes in knee-adjacent subcutaneous fat (kaSCF) are associated with changes in cartilage thickness, cartilage T Design: This study included 4644 participants from the Osteoarthritis Initiative with annual 3.0T MRIs from baseline to four years. Deep learning algorithms quantified kaSCF, cartilage thickness, and cartilage T Results: In concurrent models, a 1 SD greater annual increase in kaSCF was associated with a 0.035 SD greater cartilage thickness loss (β = -0.035; 95% CI -0.055 to -0.015; p = 0.001), but was not significantly associated with cartilage T Conclusions: While effect sizes were modest, increases in kaSCF were associated with greater cartilage thinning and, in lagged models, with greater cartilage T

Indexed as

Cartilage T2Cartilage thicknessKnee-adjacent subcutaneous fatOA progressionPain

Identifiers

PMID41852772
PMCPMC12993892

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.