Evidence map›Paper›PMID 41852733›Full record

ArticleiScience2026

Microenvironmental acidosis drives PARP- and ATM inhibitor resistance in p53 deficient pancreatic cancer.

Renata Ialchina, Thomas René Simonsen, Henriette Berg Andersen, Arnaud Stigliani, Yifan Dai, Jiayi Yao, Tanja Larsen, Dominika Czaplinska, Luis A Pardo, Albin Sandelin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Renata IalchinaSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Thomas René SimonsenSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Henriette Berg AndersenSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Arnaud StiglianiSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Yifan DaiSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Jiayi YaoSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Tanja LarsenSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Dominika CzaplinskaSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Luis A PardoOncophysiology Group, Max Planck Institute for Multidisciplinary Sciences (MPI-NAT), Göttingen, Germany.
Albin SandelinSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Stine Falsig PedersenSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor suppressor p53 inactivation and an acidic microenvironment are pancreatic ductal adenocarcinoma (PDAC) characteristics supporting disease aggressiveness and treatment resistance. Using murine early PDAC (PanIN) organoids and CRISPR-Cas9 knockout (KO) of p53, we show that the molecular acid-base regulation machinery, intracellular pH (pH

Indexed as

MicroenvironmentOncology

Identifiers

PMID41852733
PMCPMC12992510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.