Evidence map›Paper›PMID 41852640›Full record

ArticleACS pharmacology & translational science2026

Impact of Side Chain Structure and Aglycon Carbonyl Group on the Immunostimulatory Activities of Semisynthetic Saponin Adjuvants.

Di Bai, Liz Wang, Rebekah Beyea, Hyunjung Kim, Pengfei Wang

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Di BaiDepartment of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
Liz WangDepartment of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
Rebekah BeyeaAdjuvax LLC, 2000 9th Avenue South, Birmingham, Alabama AL35205, United States.ORCID https://orcid.org/0009-0005-6165-4336
Hyunjung KimAdjuvax LLC, 2000 9th Avenue South, Birmingham, Alabama AL35205, United States.
Pengfei WangDepartment of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.ORCID https://orcid.org/0000-0002-0285-2069

Funding

Optimize VSA Adjuvants through Medicinal Chemistry Study75N93025C00007 · NIAID · ADJUVAX LLC · 2025 to 2025
$3.0M
NIAID NIH HHS 75N93025C00007
6 · The paper itself

Abstract

VSA-1 and VSA-2 are recently developed semisynthetic saponin immunostimulants derived from natural

Indexed as

Momordica saponinssaponin immunostimulantvaccine adjuvantVSA-1VSA-2

Identifiers

PMID41852640
PMCPMC12993776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.