Evidence map›Paper›PMID 41852549›Full record

ArticleAddictive behaviors reports2026

Improvements in substance use and social determinants of health associated with hepatitis C treatment initiation and sustained virologic response in opioid treatment programs.

Andrew H Talal, Raktim Mukhopadhyay, Valentina Veronesi, Arpan Dharia, Giovanni Saraceno, Daniel S Fierer, Marianthi Markatou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addictive behaviors reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew H TalalDivision of Gastroenterology, Hepatology and Nutrition, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 875 Ellicott Street, Suite 6090, Buffalo, NY 14203, USA.
Raktim MukhopadhyayDepartment of Biostatistics, School of Public Health and Health Professions, University at Buffalo, 726 Kimball Tower, 3435 Main Street, Buffalo, NY 14214, USA.
Valentina VeronesiDepartment of Biostatistics, School of Public Health and Health Professions, University at Buffalo, 726 Kimball Tower, 3435 Main Street, Buffalo, NY 14214, USA.
Arpan DhariaDivision of Gastroenterology, Hepatology and Nutrition, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 875 Ellicott Street, Suite 6090, Buffalo, NY 14203, USA.
Giovanni SaracenoDepartment of Biostatistics, School of Public Health and Health Professions, University at Buffalo, 726 Kimball Tower, 3435 Main Street, Buffalo, NY 14214, USA.
Daniel S FiererDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave Levy Place, New York, NY 10029, USA.
Marianthi MarkatouDepartment of Biostatistics, School of Public Health and Health Professions, University at Buffalo, 726 Kimball Tower, 3435 Main Street, Buffalo, NY 14214, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although opioid use disorder (OUD) and hepatitis C virus (HCV) frequently co-occur, few studies have evaluated substance use and social determinants of health (SDOH) that predict HCV treatment initiation and sustained virologic response (SVR). Methods: We used administrative and clinical trial outcome data from HCV-infected methadone-treated participants ( Results: HCV treatment approach ( Conclusions: We identified changes in substance use and SDOH associated with HCV treatment initiation and SVR. Individual and regional-level subgroup differences could guide intervention implementation. HCV treatment initiation and SVR lead to improvements, not only in liver and infectious diseases outcomes, but in social and substance use factors.

Indexed as

ClusteringIntegrated hepatitis C virus-opioid use disorder treatmentOpioid use disorder treatmentSocial determinants of healthViral hepatitis

Identifiers

PMID41852549
PMCPMC12993007

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.